Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting
نویسندگان
چکیده
منابع مشابه
Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting
Imprinted genes are regulated by allele-specific differentially DNA-methylated regions (DMRs). Epigenetic methylation of the CpGs constituting these DMRs is established in the germline, resulting in a 5-methylcytosine-specific pattern that is tightly maintained in somatic tissues. Here, we show a novel epigenetic mark, characterized by strand-specific hemimethylation of contiguous CpG sites aff...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2017
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkx518